"Estranged" is the centerpiece of Use Your Illusion II and one of the most ambitious recordings in the Guns N' Roses catalog. Spanning over nine minutes, the track was written by Axl Rose and features an orchestral scope that encompasses multiple movements, tempo changes, and emotional registers. The recording includes a piano solo from Rose himself, a rare instrumental feature that emerges midway through the track with a delicate, classical-influenced quality at approximately 87 BPM in the key of B. Slash contributes two commanding guitar solos that provide the song's most visceral moments, the first building with controlled intensity around 90 BPM and the second erupting near the song's conclusion at about 93 BPM with soaring, emotionally cathartic phrasing. The composition traces the arc of a disintegrating relationship with cinematic grandeur, moving from quiet desperation through anger to a kind of resigned transcendence. The arrangement incorporates synthesizers, strings, and layered vocal harmonies alongside the core rock instrumentation, creating a sonic panorama that rivals the most elaborate productions of the era. Estranged was accompanied by a lavish music video and stands as perhaps the definitive artistic statement of the Use Your Illusion project.